Trish was born a boy, a boy who always felt he harbored a female inside him. Struggling to deal with her sexual identity, Trish, who then called herself Melinda, passes through a world of female impersonators, some of whom make a living on the side as prostitutes. When she meets Evan, while is attracted to him romantically and sexually, she is sure that she can never fit into his world; in her mind, she would be a man sleeping with another man. Although Evan also has some doubts about the relationship, he and Trish pull together to make it, and their sex life, work.
While Evan and his children accept her as the lady of the house, old friends from the drag club resurface and threaten to upset the beautiful suburban life Trish has made for herself, even as the head of a top modeling agency (with a secret of her own to protect) tries to sign Trish to a lucrative endorsement contract.